Leaky Gut Syndrome (Intestinal Permeability Syndrome)

Matthew Capowski

Staff member
Amyloid-DNA Composites of Bacterial Biofilms Stimulate Autoimmunity http://www.cell.com/immunity/abstract/S1074-7613(15)00224-1

Summary: Research on the human microbiome has established that commensal and pathogenic bacteria can influence obesity, cancer, and autoimmunity through mechanisms mostly unknown. We found that a component of bacterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during biofilm formation. This interaction accelerated amyloid polymerization and created potent immunogenic complexes that activated immune cells, including dendritic cells, to produce cytokines such as type I interferons, which are pathogenic in systemic lupus erythematosus (SLE). When given systemically, curli-DNA composites triggered immune activation and production of autoantibodies in lupus-prone and wild-type mice. We also found that the infection of lupus-prone mice with curli-producing bacteria triggered higher autoantibody titers compared to curli-deficient bacteria. These data provide a mechanism by which the microbiome and biofilm-producing enteric infections may contribute to the progression of SLE and point to a potential molecular target for treatment of autoimmunity.​

The above article suggests a new mechanism, or a more subtle understanding of the mechanisms involved, in regards to the processes that bring about an autoimmune response. Biofilms created by bacteria, whether as a result of infection or healthy bacterium in the case of leaky guy, may be triggering the autoimmune response.

NueroScientistNews has a good write up about this study titled: Research team finds bacterial biofilms may play a role in lupus, MS, other auto-immune diseases

A team led by TUSM researchers Çagla Tükel, PhD, and Stefania Gallucci, MD, show how bacterial biofilms found in the gut can provoke the onset of lupus in lupus-prone mice and is published in the journal Immunity.