Vitamin D

Matthew Capowski

Matthew Capowski

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This thread is for the discussion of Vitamin D.

Peter Bergman, Anna-Carin Norlin, Susanne Hansen, Rokeya Sultana Rekha, Birgitta Agerberth, Linda Björkhem-Bergman, Lena Ekström, Jonatan D Lindh, Jan Andersson. Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open, 2012; 2: 6 e001663 DOI: 10.1136/bmjopen-2012-001663

Paul Bergner's summary of the above article from his twitter: "Vitamin D 4000 iu/day for 1 year reduced colds by 25% and antibiotic use by 50%".

The Vitamin D Council in particular is a good resource and they offer a home testing kit.

The Weston Price Foundation has some valuable reads (although do keep in mind that their paradigm of high Vitamin A with Vitamin D differs from the Vitamin D council and it's not clear which proposal is more accurate):

http://www.westonaprice.org/health-topics/faq-supplements/
http://www.westonaprice.org/blogs/c...amins-a-and-k-testimonials-and-a-human-study/
http://www.westonaprice.org/blogs/c...-naked-ape-hypothesis-of-optimal-serum-25ohd/
http://www.westonaprice.org/health-topics/update-on-vitamins-a-and-d/
http://www.westonaprice.org/blogs/c...ople-pushing-their-vitamin-d-levels-too-high/
 
Matthew Capowski

Matthew Capowski

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Science Daily has an interesting article titled Low and high vitamin D levels in older women associated with increased likelihood of frailty about the following study:

Kristine Ensrud et al. Circulating 25-hydroxyvitamin D Levels and Frailty Status in Older Women. Journal of Clinical Endocrinology & Metabolism, December 2010

"...lower and higher vitamin D levels were associated with an increased likelihood of frailty in older women." The lower levels part was expected. The higher levels part is more interesting. Vitamin D researchers have always been aware there is an upper limit to one's vitamin D levels as well as diminishing returns for increased supplementation. But establishing what that ideal range is remains a useful research question.
 
Matthew Capowski

Matthew Capowski

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Mayo Clinic. "Vitamin D toxicity rare in people who take supplements, researchers report." ScienceDaily. ScienceDaily, 30 April 2015. www.sciencedaily.com/releases/2015/04/150430134852.htm

Americans have low vitamin D levels, research shows, and as a result, vitamin D supplement use has climbed in recent years. Vitamin D has been shown to boost bone health and it may play a role in preventing diabetes, cancer, cardiovascular disease and other illnesses. In light of the increased use of vitamin D supplements, researchers set out to learn more about the health of those with high vitamin D levels. They found that toxic levels are actually rare.
Click to expand...
 
Matthew Capowski

Matthew Capowski

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Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn’s disease: Results from a randomised double-blind placebo-controlled study [PDF file of study]

The above study finds that 2000IU/day for 3 months helped reduce both inflammation in Chrohn's disease and reduced intestinal permeability.
 
Matthew Capowski

Matthew Capowski

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Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults:
http://archneur.jamanetwork.com/article.aspx?articleid=2436596

From the conclusion of the study:

Low VitD status was associated with accelerated decline in cognitive function domains in ethnically diverse older adults, including African American and Hispanic individuals who exhibited a high prevalence of VitD insufficiency or deficiency. It remains to be determined whether VitD supplementation slows cognitive decline.​
 
Matthew Capowski

Matthew Capowski

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This podcast discusses the VITAL study referenced below: http://www.vitamindcouncil.org/blog/vitamin-d-council-podcast-11-dr-joann-manson/

The VITAL Study is an ongoing research study in 25,874 men and women ages 50 and up in the U.S. The goal of the study is to determine whether vitamin D supplementation of 2000 IU daily or omega 3 fatty acids reduces the risk for developing cancer, heart disease and stroke in healthy adults. The study will end in 2018, totaling a five year duration. This study will provide enormous insights regarding the benefits of vitamin D and omega 3 supplementation. In this episode, Dr. John Cannell discusses the VITAL Study and its potential clinical implications with Dr. Joann Manson.​
 
Matthew Capowski

Matthew Capowski

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Matthew Capowski

Matthew Capowski

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Large, single-dose, oral vitamin D supplementation in adult populations: a systematic review. https://www.ncbi.nlm.nih.gov/pubmed/24246341

CONCLUSION:

This review recommends that vitamin D3 be used for supplementation over vitamin D2 and concludes that single vitamin D3 doses ≥300,000 IU are most effective at improving vitamin D status and suppressing PTH concentrations for up to 3 months. Lower doses, however, may be sufficient in certain populations. Vitamin D doses >500,000 IU should be used judiciously in order to minimize adverse events.
 
Matthew Capowski

Matthew Capowski

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Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial https://academic.oup.com/jcem/article-abstract/105/4/dgz212/5634116?redirectedFrom=fulltext

Conclusions:

The safety profile of vitamin D supplementation is similar for doses of 400, 4000, and 10 000 IU/day. Hypercalciuria was common and occurred more frequently with higher doses. Hypercalcemia occurred more frequently with higher doses but was rare, mild, and transient.
 
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